Background: Preterm labor is a curable illness associated with a high risk of neonatal morbidity and mortality; the prevalence of preterm birth is rising globally which can be reduced by applying Evidence-based interventions. Aim: The study aimed to study the effect of applying standardized evidence-based practices among risk women for preterm labor on birthing outcomes. Design: Quasi-experimental study design (pre & post-test) was utilized. Settings: The study was carried out the obstetric emergency unit, obstetric out-patient clinic, and obstetric &gynecological department affiliated to Benha university hospital, Egypt. Sample: a purposive sample of 140 pregnant women at high risk for preterm labor. Tools: three tools were used; first: A structured interviewing questionnaire sheet, second: lifestyle assessment sheet and the third: maternal and fetal outcome record. Results: there were a high statistical improvements in maternal outcomes as women`s experience of delivery, complications of present delivery, presence of post-partum complications, and hospitalization days as the p-value ≤ 0.00. there were a high statistical differences in improvements of the study group compared to control ones regarding fetal outcomes as birth weight, Apgar scores (1st min & 5th min), newborn condition, and neonatal complications p-value ≤0.001. Conclusion: There were progressive improvements in birth outcomes after applying standardized evidence-based practices of the study group in compared to the control group p-value ≤ 0.001. Recommendations: Increase awareness regarding Standardized Evidence-Based practices regarding preterm in all maternity units.