The strain on nurses to make decisions about frequently challenging problems to solve has increased as a result of the swift changes within healthcare systems. The way people think has a big impact on how they work together to deliver high-quality healthcare. Polarity thinking can bring predictability and stability while also simplifying complexity without alienating the various groups. Study aim to: Assess the effect of polarity thinking training program on intra-professional collaboration among nursing staff. Research design: Quasi-experimental research design was used. Setting: The present study was conducted at Sohag University Hospital. Subjects: 76 members of nursing staff (Head nurses- Nurses) participated in the study. Tools: Three tools were used demographic data sheet, Polarity map application test, and Nurse-Nurse Collaboration behavior scale. Results: About (79%) of participants had low level of intra professional collaboration pre-program, while (61%) of them had moderate level post program. And polarity map level were good (71.05%) at post comparing with poor score (97.37%) at pre-program. Conclusion: There was a positive highly significant correlation between polarity thinking and intra-professional collaboration. Recommendations: Enhance the curriculum of nursing administration course in nursing faculties of Egyptian universities with learning activities about polarity thinking. Nurse Managers should display collaboration behaviors to construct an engaging climate, through using polarity thinking.