Crisis management is the actions of managers and leaders. Effective response to the crisis and coordinating between strategic plan and leadership styles help in managing it. Aim: To determine the most effective leadership styles in health crisis management (HCM) from nurses' perspective. Methods: This explorative study incorporated a convenience sample of 282 nurses who worked at chest, ICUs, medical, orthopedic departments, ORs, emergency, and surgery units at Qena University Hospitals (QUHs). Tools: Two tools were used: Leadership questionnaire, crisis management (CM) questionnaire. Results: The uppermost mean score of leadership styles were connected to transformational leadership (32.46±7.8) while the lowest was related charismatic leadership. There were a positive statistically significant correlation between leadership styles and CM. Conclusion: All transformational, transactional and charismatic leadership styles are effective in HCM but the studied nurses' preferred transformational leadership styles compared to both other leadership styles. Recommendations: Department heads of CM should receive concentrated training before being assigned to such positions and implement training courses about CM for nurses who are working in critical departments and whose have managerial and leadership positions.