Stroke is a major public health problem affecting primarily older adults. Aim: To determine the effect of an educational program on the knowledge and practices of geriatric patients about stroke prevention at Assiut University Hospital. Subjects and Methods: A randomized control trail design was used. The current study included 170 geriatric patients (85 study group and 85 control group) in outpatient clinics. Three tools were used: Socio-demographic and clinical data on geriatric patients, structured interview schedules, patients' knowledge about stroke prevention, and patients' practices about stroke prevention Results: The study revealed that the mean scores of their knowledge rose from 25.58 ± 9.92 pre-program intervention to 47.91 ± 7.14 immediately post-program and 37.56 ± 4.62 three months post-program, while 71% of the studied geriatric patients had a poor practice score that decreased to 15.3% after three months of program implementation. Conclusion: There was a significant statistical difference between the pre-test program and the follow-up program in knowledge score and practice score. Recommendation: Periodic health education programs should be implemented to increase awareness and involve stroke-risky patients in program design and monitoring.