Peripheral intravenous (IV) cannula is the most used invasive method for delivering fluids and medications. It can be associated with complications; therefore, prompt intervention is required by nurses. The study aimed to evaluate the effect of nursing training regarding the care and maintenance of peripheral intravenous cannula on nurses' performance and the incidence of intravenous complications. Design: quasi-experimental was used. Setting: Medical and surgical wards at Menoufia University Hospital. Subjects: A convenience sample of all available nurses (n=50) working in the medical and surgical wards and a purposive sample of 80 adult patients participated in the study. Four tools were used: Tool 1: The nursing demographic data sheet, Tool II: the nurses' knowledge selfadministered questionnaire sheet, Tool III: the nurses' practice self-administered questionnaire sheet, and Tool IV: the related Local Complications with Peripheral Intravenous Cannula Observational Checklist. The results: The obtained data confirmed the proposed study hypotheses. After receiving nursing training, there was a noticeable improvement in the performance of nurses. Furthermore, the study group showed a notable reduction in the incidence of peripheral IV cannula-related local complications compared to the control group, including blockage, phlebitis, infiltration, and local infection. The study concluded that the implementation of the nursing training resulted in significant improvements in nurses' knowledge and practice, as well as lowering the incidence of local complications related to peripheral IV cannula. The study recommended that prior to caring for patients in a medical-surgical setting who are utilizing peripheral IV cannula, nursing training should be considered helpful.