ack ground: Esophageal varices that are at risk of rupturing can be treated with variceal banding. Aim of the study: Design and implement nursing instructions for patients undergoing endoscopic band ligation for esophageal varices at Assuit University in Al-Rajhi Hospital. Research design: Quesi experimental research design, study and control was utilized in this study. Subjects: The sample of 60 adult patients with esophageal varices 30 patients in each group. Setting: The study was conducted in Gastrointestinal Endoscopy Unit and Gastroenterology Departments at Al-Rajhi Hospital. Tools: (I): Patient assessment sheet. (II): Patients, knowledge questionnaire regarding esophageal varices band ligation and Nursing instructions for patient undergoing esophageal varices band ligations. Results: Recurrent of esophageal varices among studied group was 36.7% compared 93.3% for control group after application of nursing instructions. Conclusion: Esophageal varices recurrence after band ligation was reduced after provided nursing instructions for the patient, Recommendation: Continuous follow up programs and compliance of instructions to reduce recurrence esophageal varices after endoscopic band ligation.