Background: Nocturnal Enuresis (NE) is a common, genetic, complex, heterogeneous and one of the most frustrating and disturbing problems for both children and their parents. Aim of the study: To evaluate the effectiveness of the bidirectional multimodal intervention program on nocturnal enuresis reduction among school age children in Mansoura City, Egypt. Settings: The study was carried out in the Involuntary Urination Outpatient Clinic at Mansoura University Children Hospital (MUCH) and the Enuresis Clinic at Shams Center of Pediatrics and Newborns. A purposive sample of 126 parents and their children suffering from NE. Tools of data collection: A Structured Interview Questionnaire form for the Studied Parents and a Structured Interview Questionnaire form for the Studied Children were used. Results: 4.8% versus 100% and 94.4% of the studied parents had good total knowledge scores as well as none versus 100% and 95.2% of them had satisfactory total reported practices scores about NE pre, immediate post and post 3 months of program implementation respectively. Moreover, 93.7% of the studied children had bedwetting more than once a week pre-program; while, post 3 months after program implementation, 55.6% of them had bedwetting once a week. Conclusion: Parents' level of knowledge and their reported practices about NE was significantly improved post program. Bedwetting frequency among the studied children was decreased post 3 months after program implementation. Recommendations: Continuous educational program for parents of children with NE is essential to update their knowledge and skills about advanced treatment strategies.