Background: Entrepreneurship is widely viewed as a crucial foundation for gaining a competitive edge in nursing field and improving new graduated nurses' ability for professional development and career aspiration. Aim: Assess entrepreneurial tendencies of new graduated baccalaureate nurses and its relation to their professional development and career aspiration. Research Design: The study used a descriptive correlational design. Setting: The study was conducted at Benha University Hospital in Medical, Surgical and Critical Care Units. Sample: All available of new graduated baccalaureate nurses (140) were incorporated into the study. Tools of data collection: Three main tools namely; I): Entreprene0020urship scale. II): Professional development questionnaire. III): Career Aspiration Scale – Revised (CAS-R). Results: About two thirds (66.7%) of new graduate baccalaureate nurses had moderate level of entrepreneurial tendencies, more than half (55.7%) of them had moderate perception level toward professional development and more than two thirds (71.4%) of them had high level of career aspiration. Conclusion: There was a positive highly statistically significant correlation among total entrepreneurial tendencies, total perception toward professional development and total career aspiration among new graduated baccalaureate nurses. Recommendations: Raising awareness of new graduated nurses about entrepreneurship through frequent scientific meetings to make them more successful in the professional life and achieve their career aspiration. Conducting a study to determine how an entrepreneurship training program affects the clinical competency of newly graduated baccalaureate nurses.