Background: Hospitals are a knowledge-based environment due to speedily changing medical technologies and demanding knowledge and skillful capital. Job crafting, knowledge sharing, and career resilience play a remarkable role in enhancing their performance effectively and efficiently. The aim of the study: This study aimed to assess the relationship between job crafting, knowledge sharing, and career resilience among nurses at Suez Canal University hospital. Subjects and Method: Research design: A descriptive correlational research design. Setting: The study was conducted in different departments and units at Suez Canal University Hospital. Subjects: A simple random sample of 320 staff nurses from different departments and units in the previously mentioned study settings. Tools of data collection: Data were collected using a job crafting scale, knowledge sharing scale, and career resilience scale. Results: 88.3% of staff nurses had moderate agreement level regarding job crafting, the majority of them had a moderate knowledge-sharing level (74.1 %), and the mean score for resilience was (3.76 ± 0.45). Conclusion: There was a highly statistically correlation between knowledge sharing and job crafting. Also, there was a statistically correlation between nurses' career resilience and job crafting. Recommendations: Integrate the concepts of knowledge sharing, and career resilience into the main values and integrate them in strategic management and encourage and provide support to staff nurses through open communication, problem-solving, and shared decision making