Background: Information technology competence integration and its relation to providing electronic health facilities are main concerns in numerous countries around the world. The development and implementation of e-health strategies is regarded as a priority for the health care system. Aim: This study aimed to detect the relation between nurses' IT competence and their attitude to e- health solutions at Mansoura University Children Hospital. Research design: A descriptive correlational research design was utilized. Subjects: A convenient sample consisted of 123 staff nurses were enrolled in the study. Tools: Data were collected by using a self-administrated questionnaire in addition to a question concerned with assessing nurses' opinion of the impact of new technologies and the internet on lives of modern people as well health care. Results: The study findings revealed that majority of the staff nurses have high level of IT competence. As well, more than half of staff nurses agreed upon usefulness of the presence of new technologies in the lives of modern people. Conclusion: The relation between nurses' IT competence and assessment of the influence of the internet and new technologies on health care and lives of modern people was a highly significant. Also, there was a highly significant relation between nurses' IT competence and recommendation of e-health solutions. Recommendation: Promoting the concept of embedding electronic health solutions and telenursing through health care organizations and conducting continuous training programs for sustaining information technology competency levels.