Background: Nurses consider the health care professionals who firstly transact with, identify the need for and initiate cardiopulmonary resuscitation (CPR). Understanding Perception of roles and team performance regarding Cardiopulmonary resuscitation are important for nurses to effectively meet clients' unique needs in CPR. Aim: To explore Nurses' Perception regarding Cardiopulmonary resuscitation. Design: Descriptive research. Setting: The study conducted in trauma intensive care unit and general intensive care unit at Assiut University. Subject: all nurses available in trauma intensive care unit and general intensive care unit (85nurses) at Assiut University. Tools: One tool was utilized to collect the relevant data, A self-administered questionnaire that examined nurses' perception and divided into four parts, Personal characteristics, nurses' perception toward importance of CPR, nurses' roles and team performance regarding CPR. Results: More than two third (75.41%) of nurses had a great perception about CPR With (58.8%) Satisfactory level of nursing CPR Perception. Nurses agreed that Cardiopulmonary resuscitation is important in clinical practice, identified perception of roles and perceptions towards team performance during CPR. Conclusion: The nurses had a great perception regarding CPR but they feel that CPR is complex, time consuming, energy consuming and a stressful situation and nurses in CPR team have limited knowledge about DNR (Don't resuscitate). Recommendations: Adequately planned in-service training programs related to CPR should be established for improving nurses' knowledge, practice and nurses' ability to think critically during the performance of CPR.