Background: Oral health among children usually is an indicator of their well-being, overall health and quality of life. Poor oral hygiene due to oral self-care deficit and dental visits infrequency is a main cause for the dental problems as dental caries, gingival disease, loose teeth, bad breath and oral trauma. Aim: The current study aimed to assess the oral health related knowledge, practices and quality of life among school age children. Method: Descriptive correlational design was utilized; the study was implemented in Dental Clinics in Comprehensive Health Insurance Primary Care Centers in Ismailia City (Hay-elsalam, El-shohda and Araieshiet Misr Family Medicine Centers). The study subjects comprised (308) children. Four tools of data collection were utilized namely; Oral Health Structured Interviewing Questionnaire, Oral Health related Habits Assessment Sheet, An Observational Checklist for Oral Hygiene Practice and Children Oral Health related to Quality of Life Scale Version 25. Results: most of the studied children and more than two thirds (92.9% and 68.8%) of them had good knowledge and had good oral health related quality of life (OHRQoL) respectively. While, most and the majority (89.9% and 83.4%) of them had poor oral health related habits and didn't brush their teeth correctly. Conclusion: Most of the studied children total levels of knowledge was good, while most of them had poor oral health related habits. The majority of them didn't brush their teeth correctly and more than two thirds of them had good OHRQoL. Recommendations: Promotion programs related to oral health are required for raising oral health knowledge, practices and quality of life among children.