Background: Students in health fields have been found to have compassion fatigue, which can be attributed to the long hours of study and high stress levels of their clinical work and lead to emotional exhaustion, decreased empathy, and feelings of detachment from patients. In Egypt, not much thought was given to how likely psychiatric nursing students were to be affected by ProQOL and related conditions. Aim: To explore the factors that impact a ProQOL in undergraduate psychiatric and mental health nursing students. Subjects and Methods: 270 nursing students participated in this study. A survey was conducted that comprised three scales in addition to sociodemographic and academic data: the Perceived Stress Scale, the ProQOL Scale (5), and the Core SelfEvaluations Scale. Results: Three quarters of the psychiatric nursing students reported a low quality of life at work. This was associated with moderate levels of core self-assessment and perceived stress scores, with a negatively significant association between job quality and core self-assessment and perceived stress scores. In addition, the results revealed that age, part-time employment status, total core self-report scale score, and perceived stress scale are important predictors of ProQOL in psychiatric nursing students. Conclusion& Recommendations: These results call for the development of pedagogical solutions that include stress reduction strategies, relaxation techniques, peer mentoring and measures to improve the ProQOL.