Background: Intensive care unit patients had a life-threatening condition and muscle weakness that caused active movement limitations and bathing ability. Aim: To identify the hazards associated with intensive care unit bed hygienic nursing care practices. Research design: A prospective descriptive research design was used. Setting: The study was conducted in general intensive care units at Al-Behera hospitals in Egypt. Population: 120 nurses and 270 patients were included. Tools of data collection: Tool one was developed that consisted of three parts. Tool two was used to determine hazards associated with bed hygienic nursing practices Results: 71% of studied patents were male with a mean age of 49.09±6.12. The mean of ICU days was 14.06±5.01. 70.8% of studied nurses was female with a mean age of 28.07±4.23. Risk of fall (99.9%) and dislodgment of invasive devices were the most hygiene hazards related to patients. Ratio of nurses to patients (99.3%) and lack of staff assistance (98.5%) were also most hazard related to nurses. While lack of equipment (99.9%) was the most environmental factor. Conclusion: Multivariate analysis logistic regression for hygiene hazards in studied patients were discontinuous from mechanical ventilator, medications, invasive devices, changing position, and nurses with chronic back pain and ICU beds. Recommendation: In-service training and continues workshops to train in hygiene practice is needed. Nurses in charge should have skills to supervise and observe nurses' performance and poor hygiene practices should be modified.