Background: Weaning from mechanical ventilation frequently relies on individual decision and expertise. This could lengthen the duration of the mechanical ventilation link and raise healthcare costs. Therefore, the present study aimed to compare between Burn's Wean Assessment Program and the routine method on outcomes of mechanically ventilated patients at Sohag University Hospital. Three research hypotheses were formulated. Quasi experimental research design was used. The study was carried out in the general intensive care unit. A convenience sample of 110 adult male and female patients connected to mechanical ventilators for more than 72 hours were recruited to fulfill the purpose of this study. They were divided randomly into two equal matched groups. four tools were used to collect data pertinent to this study which are; Ι) Routine Weaning Assessment sheet for Mechanically Ventilated Patients, ΙΙ) Burn's Wean Assessment Checklist, Ш) Mechanically Ventilated Patient's outcomes Assessment sheet and Ш) APACHE II Finding of this study documented a reduction of MV connection time period no patients connected on mechanical ventilation above 10 days in study group while 17patients(30.9%)in control with highly significant p value (.001), reduced length of hospital stay with a higher rate of success between study and control groups with highly significant p value (.001) . So the three stated research hypotheses can be supported. Conclusion: based on the study finding, it can be concluded that using BWAP seems to be much better than the routine weaning method. Recommendations: Replication of this study on a larger probability sample for generalization.