Background: The World Health Organization has specified (COVID-19) to be a contagion. People's communicable disease information, attitude, and practices (KAP) might have a great effect on whether they might detect the protective procedures. The study aimed to assess Knowledge, Attitude, Practice and psychological response of Pediatric nursing students toward COVID-19 at Assiut University. Method A descriptive research design was used. The study was done at Faculty of Nursing, Assuit University with A convenient sample of all third year the pediatric nursing students who approved to contribute in the study. Tool of data collection: four tools were used in this study Tool I: It included personal data, Tool II: It includes 28 questions about student's attitude toward spread of Covid 19, Tool III: It includes 9 questions about psychological response, Tool IV: It includes 14 questions about students practice Results: The result indicates that more than half of studied sample have adequate knowledge and negative attitude regarding covid19. The majority of studied sample (80.6%) had unsatisfactory practice and negative psychological reaction towards covid19. There is a very highly statistical significance difference between total knowledge and total practice and between total knowledge and total attitude as well. Conclusion: This study showed that the pediatric nursing students had adequate knowledge, unsatisfactory practices, negative attitude and psychological response toward the COVID19 outbreak. Recommendations: Health education programs should be developed according to their areas of knowledge and practice deficits and provided for students