Background: Compliance with post- COVID-19 pandemic precautionary safety measures will likely vary depending on the country and local government. It is expected that precautionary safety measures will continue to be enforced in public spaces to prevent further infection spread. Aim: Assess nursing students' knowledge and compliance with precautionary safety measures post covid-19 pandemic. Design: Description study. Setting: Faculty of Nursing, Damanhour University. Subjects: A convenience sample of 1080 undergraduate nursing students from the four study levels. Study tools: Two tools were used. Tool (I) Nursing students' knowledge regarding COVID-19 precautionary safety measures questionnaire and Tool (II) Nursing students' compliance with precautionary safety measures post covid-19 pandemic questionnaire. Results: Showed that (65.7%) of studied students were female, (80.0%) had fair compliance levels, and (62.7%) had good knowledge, with a highly positive correlation between knowledge, and compliance pattern among the study group (p=0.025,r=-.068*). Conclusion: Students showed good knowledge and fair compliance level, with a statistically significant relationship with most of the students' demographic characteristics. Recommendations: Nursing students are a valuable source of public information and serve as a bridge between the healthcare industry and the public. Therefore, it is important to keep abreast of the latest updates with available knowledge of preventive precautionary safety measures and obtain information from reliable resources.