Thyroidectomy is one of the most common cervical and endocrine surgeries performed today, technological advancements in thyroid surgery, mortality and morbidity rates are low, but some long-term complications occurring after thyroidectomy continue to pose a health and social problem. Aim: This study aimed to evaluate the effect of enhanced recovery protocol on neck pain and disability post thyroidectomy. Design: A pre- post technique quasiexperimental research design was used. Setting: This study was conducted at the department of General Surgery connected with New Surgical Hospital and Outpatient Surgery Clinic at Zagazig University Hospital, Sharquia Governorate, Egypt. Sample: A purposive sample of sixty patients undergoing thyroidectomy. Tools: Patients' interview questionnaire, Neck Pain Disability index Questionnaire, and Post thyroidectomy complications observational checklist. Results: There was a highly statistically significant difference between the patients in the study and control groups about the level of pain & disability at post intervention at p-value <0.001 and with Mean ±SD (10.9±4.9 & 22.1±5.8 respectively). Finally, inverse significant correlation was found between total level among the patients in knowledge, neck pain & disability in study group at post intervention (r=-0.53 p=0. 003). Conclusion: Application of enhanced recovery protocol for patients undergoing thyroidectomy had a statistically significant positive effect on alleviating neck pain, functional disability, and postoperative complications. Recommendation: Repetition of the present study on greater possibility population is advised to gain generality and larger application of the proposed protocol.