Background: Smartphones have significantly changed how lay people manage their health and illness in recent years; particularly with reference to infertility which increases psychological difficulties such as anxiety and depression. Identification of adjustment strategies for stressful events like infertility is important. Aim: Evaluate the effect of social media-based intervention on adjustment, anxiety and pregnancy rate among infertile women undergoing assisted reproductive technology. Design: A quasi-experimental pre posttest design with only one group was used for this study. Setting: The study was carried out at Minia Infertility Special Nile Center for IVF. Sample: Included a purposive sample of 100 infertile women. Tool: Four tools were used for data collection: a structured interviewing questionnaire, fertility adjustment scale, state-trait anxiety inventory, and pregnancy rate. Results: The current study revealed that half of the studied sample had low anxiety at post intervention. More than two thirds of them had good adjustment at post intervention. Furthermore, greater than half of the studied sample was pregnant after in vitro fertilization. Conclusion: This study concluded that social media-based intervention was an effective tool in improving levels of adjustment, pregnancy rate and reducing levels of anxiety among infertile women undergoing assisted reproductive technology. Recommendation: psychological support s