Background: perioperative morbidity and mortality are significant public health concerns due to their influence on patients' short- and long-term survival as well as the use of healthcare resources. The aim of this study research was to evaluate the effect of Enhanced Recovery Pathway application on perioperative outcomes among women undergoing gynecological oncology operations. Methods: A comparative quasi-experimental research design was used on a convenient sample of 112 women diagnosed with gynecological malignancy. The study group (56) got perioperative routine hospital care along with the implementation of an enhanced recovery pathway, and the control group (56) received perioperative routine hospital care only at the gynecology/ obstetrics and operating room of gynecological departments in Suez Canal University and Oncology Institute hospitals in Ismailia city. Tools: (T1) a structured interview questionnaire, (T2) assessment record for women undergoing gynecological oncology operations, (T3) Visual Analogue Scale. Results: There was a statistically significant difference between the studied groups; women who underwent gynecological oncology operation in the study group were significantly likely to experience less pain score, decrease in length of hospital stay, early postoperative bowel mobility with p-value (0.001,0.004,0.010 respectively) and decrease incidence of postoperative complications. Conclusion: As a result of the study's findings, women undergoing gynecological oncology surgery experienced fewer postoperative complications and better postoperative outcomes. Recommendation: Apply enhanced recovery pathway applications, which were successful for women following gynecological oncology surgery, to speed up recovery at the study sites and other healthcare facilities.