Background: Cigarette smoking is too prevalent and one of the prominent reasons for mortality and morbidity worldwide although negative health consequences on the general population. Mentally ill patients smoke at higher rates than the general population believing that reducing stress, enhances emotional balance, and decreases irritability. Aim of Study: To compare between emotional balance and psychological irritability among heavy cigarette smokers with/without mental disorders. Design: Descriptive correlational comparative design was used. Sample: A purposive sample of 300 males who meet the criteria of heavy smokers were divided into two groups; 150 patients in “group A" diagnosed with mental disorders and 150 patients in group B mental health employees. Setting: Group A was recruited from “the Psychiatric and Mental Health Hospital" in Meet-khalf at Menoufia, while group B employees were recruited from Menoufia University hospital who were adopted to reflect the correlation between emotional balance and psychological irritability in the presence of mental illness. Tools: SocioDemographic Data Sheet, emotional balance, and psychological irritability scales. Results: There were significant differences in emotional balance; regarding the dimensions of emotional confrontation and flexibility; and psychological irritability between groups A and B (P≤0.000, 0.001 and 0.081) respectively. Conclusion: There were significant positive correlations between psychological irritability and emotional balance in group A of mental illness, and also a highly significant difference in psychological irritability between the A and B groups (P≤0.001). Recommendation: Health education programs should be designed for the prevention and management of emotional imbalance and psychological irritability among heavy smokers with mental disorders.