A basic knowledge and practices of first aid is very important for engineers and workers in engineering sector to be able to provide emergency care in the event of an accident, possibly saving lives and minimizing injury Aim: To assess engineering students' knowledge and practice about first aid at Assiut University. Subjects and Methods: A descriptive research design and the systematic random sample were used in this study. The current study included 85 engineering students at Assiut University. Three tools were used in the study: self-administered questionnaire concerning the socio-demographic characteristics of the studied student, their knowledge about first aid, and observational checklist for student's practices about first aid Results: The study revealed that 61.2% of students had poor knowledge score about first aid while 85.9% of them had poor practice score about first aid. There were no statistically significant differences between socio-demographic data and mean knowledge and practices score among engineering students except regarding sex variable there was statistically significant difference found (p=0.000, p= 0.001). Conclusion: The engineering students show poor knowledge and practices about first aid. There was positive correlation between total score of knowledge and total score of practices with statistical significant was found. Recommendation: Educational programs should be developed for engineering students regarding first aid and prevention of engineering occupational hazards.