The accelerating aging process and growing digitalization of society have drawn more focus to the effects of smartphone use on cognitive performance and depression in older adults. Aim: To assess the relationship between smartphone use and cognitive impairment and depressive symptoms among elderly people. Design: A descriptive research design was used. Setting: the elderly club of Al-Taqwa Association, the elderly club of the Family Care Association, and the elderly club in Kafr Al-Maisleh. Sampling: A systemic random sample consisting of 270 elderly persons was included in the study (155 users and 115 nonusers of smartphone). Instruments: Three instruments were used: the Characteristics of Elderly Structured Interview Questionnaire, the Montreal Cognitive Assessment, and the Geriatric Depression Scale. Results: Mean score of total MoCA was higher in mobile users elderly than non-users (25.1 ± 3.6, 23.5 ± 4.7) respectively and the mean score of total depression was lower in mobile users elderly than non-users (4.3 ± 2.1, 5.5 ± 3.01) respectively with statistically significant difference between users and non-users. Conclusion: Usage of the smartphone was more associated with better cognitive functions and lower depression scores. Depression symptoms were associated with the elderly over 70 years old, those with a low educational level, widowed, the elderly who live alone, and those who have a low rate of social interaction. Recommendations: Providing elderly people with information on smartphone features to promote active smartphone use. Using and maximizing mobile phone features in nursing interventions can benefit senior citizens' health.