Water from the Nile River is a fundamental water supply, while groundwater is a secondary source used for domestic, industrial, and agricultural uses in the Sohag region. Groundwater quality assessment requires additional focus due to the expanding urbanization, agriculture, and population in these dry regions, as well as the scarcity of water resources and water pollution. The evaluation of groundwater quality was implemented to determine suitable safety factors for different uses. Geographically, Araya and Gz.Shandwil regions relate to Sohag governorate and is important for residence and agriculture communities to supplement water for drinking, livestock, domestic, and irrigation uses, so great efforts were performed to evaluate water resources in the studied area. Even some large settlements use groundwater for irrigation and drinking purposes. Araya and Gaziert Shandwil villages have groundwater that founds in a Pleistocene aquifer. In all groundwater samples, the principal ions (Na+, K+, Ca2+, Mg2+, HCO3-,SO42-, and Cl-) and minor chemical components (NO3-, NH4+) were analyzed. The investigation goals are to explain the potential impact of urbanization, and industrial and agricultural activities on groundwater characteristics and their purposes in different fields. The water quality is influence by natural and anthropogenic sources, which govern groundwater characteristics in the area. Na+K+HCO3 facies predominance in Arya village and Ca+Mg+HCO3 facies predominance in Gz.Shandwil village. Most of groundwater samples are suitable for drinking and Araya samples are low suitable for irrigation purposes and unsuitable for paper and fruits and vegetables industries, while Gz.Shandwil are suitable for irrigation and paper and fruits -vegetables industries.