In recent years, waste generation tends to increase in quantity as the population and living circumstances increase. Uncontrolled waste incinerators (solid waste and hospital waste) are frequently the worst offenders when it comes to dioxin leakage into the environment because of incomplete burning. Dioxins are a type of environmental contaminant that is part of the so-called “dirty dozen" a collection of hazardous substances known as persistent organic pollutants (POPs). Dioxins are primarily by-products of industrial operations such as smelting, chlorine bleaching of paper pulp, and the production of various herbicides and insecticides, although they can also be produced by natural events like volcanic eruptions and forest fires. Dioxins have an impact on several organs and systems. Dioxins removal from the ecosystem is challenging due to their persistence, resistance to biodegradation, and pervasiveness, and now dioxins toxicity is recognized as a problem that needs to be addressed right away. Nowadays, increasing attention has been paid to natural antioxidant compounds with fewer detrimental effects such as locust beans to cut down on the toxicity of different chemicals. Locust bean seed mostly includes galactomannans and flavonoids which are antioxidants and are essential in protecting cells from free radicals, which may also be beneficial in liver disease, cancer, and other diseases. Locust beans also may increase the removal of dioxin from the body. Hence, in the current review, we shed the light on the promising protective effect of Locust beans against the hepatotoxicity of dioxins and dioxin-like compounds.