The efficiency of the biopesticide, abamectin (Tervigo®) and plant extracts of lantana (Lantana camara) and peppermint (Mentha longifolia), as aqueous, ethanolic and nanoparticles was determined against the root knot nematode, Meloidogyne incognita and the reniform nematode, Rotylenchulus reniformis infecting tomato plant. All tested treatments caused a significant decrease in nematode infection parameters. Tervigo as a single application achieved the maximum percentage of reduction in nematode parameters followed by peppermint nanoparticles as a single application. Tervigo plus lantana nanoparticles showed the maximum reduction in nematode parameters. However, the triple application had a high synergistic effect on reducing nematode indices as well as achieving the maximum percentage increase in total plant height, total fresh plant weight and dried weight of leaves. It is also considered the most effective, as its values reached 36.3% (nitrogen), 30.3% (phosphorus), and 53.6% (total chlorophyll content) in tomato leaves, according to their susceptibility to M. incognita and R. reniformis. Oxamyl outperformed all treatments, with the percentage of reduction in total phenol reaching 26.2%. Simultaneous application showed a significant increase in salicylic acid compared to nematodes alone and single use. The highest percentage of increase (34.5%) in salicylic acid was recorded with the triple application. Oxamyl outperformed all treatments with an increase in salicylic acid (38.2%).