Epigenetic traits, influenced by changes in chromosomes rather than DNA, are crucial for controlling biological processes. Genetic imprinting, a unique aspect of epigenetics, involves intergenerational inheritance and affects gene expression in a parent-of-origin-dependent manner. This abstract explores the concept of genetic imprinting, including its implications in gene regulation and its role in imprinting disorders such as Prader–Willi syndrome and Angelman syndrome. Genomic imprinting theories, such as kinship theory and sexual antagonism theory, shed light on the evolutionary origins and importance of epigenetic information. Gene silence, facilitated by DNA methylation, histone modification, and non-coding RNA, plays a key role in genetic imprinting processes. Clinical trials are underway to better understand and develop treatments for genetically imprinted diseases. Join us as we delve into the complexities of genetic imprinting and its impact on epigenetics.