Since it was brought to Egypt in 2006, avian influenza virus has full-fledged to be one of the most prevalent and dangerous respiratory viruses. Over time, the avian influenza viruses have undergone significant evolution and grown increasingly due to antigenic drift and shift with difficulty to control. In recent years, Egypt's chicken industry has struggled to contain this disease due to maintenance of circulation of old avian influenza virus subtypes and development of new subtypes among Egyptian poultry flocks. Additionally, circulation of other respiratory viral pathogens, for example, infectious bronchitis virus & velogenic Newcastle disease virus strains have complicated process of control of AIV infection in Egypt.  In the current review, we shed the light on the virus pathogenesis including effect of viral proteins and epidemiology with special focus on the significance of diverse infections between avian influenza virus along with additional respiratory pathogens, which generate more deadly symptoms and rapid bird deterioration.‎