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326278

Rutin Attenuates Oxidative Stress Associated with Aging: Molecular Docking Study

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Last updated: 24 Dec 2024

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Abstract

Aging is one of the major risk factors associated chronic diseases. Oxidative stress is one of the aging associated mechanisms induced by pro-oxidants. Oxidative stress is an imbalance between free radicals and antioxidants in body cells. In the current study, we investigated the molecular docking scores of rutin with aging associated biomarkers, including human β-galactosidase, caspase-8, caspase-9, caspase-3, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PK3CD), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (PK3CG), and RAC-alpha serine/threonine-protein kinase (AKT1). All proteins were retrieved from RCSB PDB database (https://www.rcsb.org/), while rutin three-dimensional structure was obtained from PubChem database (https://pubchem.ncbi.nlm.nih.gov/). The docking process was achieved by InstaDock software (https://instadock.webs.com/) and visualized by BIOVIA Discovery Studio Visualizer software. Rutin exhibited binding affinity (pKi) against AKT1, PK3CD, PK3CG, β-galactosidase, caspase-8, caspase-9, and caspase-3 of 7.85, 7.04, 6.89, 6.82, 5.94, 5.57, and 5.50, respectively. The obtained data revealed that rutin exhibited marked binding affinity to these biomarkers revealing its anti-aging potential.

DOI

10.21608/djvs.2022.165692.1096

Keywords

Molecular docking, Rutin, aging, apoptosis

Authors

First Name

Ali

Last Name

El-Far

MiddleName

H.

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt

Email

ali.elfar@damanhour.edu.eg

City

Damanhour, Egypt

Orcid

0000-0001-9721-4360

First Name

Shaimaa

Last Name

Saafan

MiddleName

Mohamad

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt, Department of Biochemistry, Animal Health Research Institute (AHRI), Damanhour Branch, Agriculture Research Centre (ARC), Damanhour 22511, Egypt

Email

saafanshaimaa@gmail.com

City

-

Orcid

-

First Name

Shymaa

Last Name

Mohamed

MiddleName

A.

Affiliation

Molecular Biology, Molecular biology unit, Medical Technology Centre, Medical Research Institute, Alexandria University, Egypt

Email

shymaa.abdullah@alexu.edu.eg

City

-

Orcid

-

First Name

Fayza

Last Name

El Tedawy

MiddleName

A.

Affiliation

Department of Biochemistry, Animal Health Research Institute (AHRI), Damanhour Branch, Agriculture Research Centre (ARC), Damanhour 22511, Egypt

Email

fayzaeltedawy@gmail.com

City

Damanhuor

Orcid

-

First Name

Abdelwahab

Last Name

Alsenosy

MiddleName

A.

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt

Email

dr_alsenosy_2010@yahoo.com

City

KAFR EL-DAWAR

Orcid

0000-0002-2262-7555

Volume

10

Article Issue

2

Related Issue

43246

Issue Date

2023-11-01

Receive Date

2022-09-28

Publish Date

2023-11-01

Page Start

32

Page End

37

Print ISSN

2636-3003

Online ISSN

2636-3011

Article File

DJVS_Volume 10_Issue 2_Pages 32-37.pdf

PDF . 924.3kB

Link

https://djvs.journals.ekb.eg/article_326278.html

Detail API

https://djvs.journals.ekb.eg/service?article_code=326278

Order

326,278

Type

Original Article

Type Code

1,001

Publication Type

Journal

Publication Title

Damanhour Journal of Veterinary Sciences

Publication Link

https://djvs.journals.ekb.eg/

MainTitle

Rutin Attenuates Oxidative Stress Associated with Aging: Molecular Docking Study

Details

Type

Article

Created At

24 Dec 2024