In the digital era, Information and Communication Technology (ICT) has a significant role in our life. Especially E-learning has been a powerful tool transforming education and training and fostering the process of empowering women which is an important goal in achieving sustainable development worldwide.The purpose of this study is to investigate to what extend ICT, as E-Learning, influence women empowerment economically and uncover the role of NGOs in supporting women empowerment and strength benefits of E-leaning towards women empowerment in Upper Egypt. In conclusion, the study highlights the potentials of e-learning for empowering women emphasizing the importance of enhancing the activities of NGOs such as National Council of women to foster women empowerment and facilitate the role of E-Learning in developing women in Upper Egypt. the Egyptian government can reduce the bureaucratic process to ease and fasten the implementation process. Further, the private sector can provide financial resources to help NGOs sustain their programs. The other potential solution is training for NGOs in capacity building to ensure effectiveness and sustainability.The research problem addressed is about the impact of e-learning on the women empowerment economically in Upper Egypt.