This study investigates alternatives for urban tissue design that can effectively mitigate and adapt to climate change. The research centers on urban regions in Egypt, examining various urban tissues to evaluate their effectiveness in enhancing thermal comfort and adapting to challenging climatic conditions. By employing comparative analytical methodology, the paper re-views multiple case studies on urban tissue design techniques aimed at climate change mitigation and adaptation. This comprehensive analysis provides valuable insights into the efficacy of different urban design strategies for fostering resilient and sustainable urban environments. The study examples analyze crucial factors of urban tissue, including building height, street direction, and incorporation of green spaces according to climatic factors. The analytical study shows the effectiveness of optimal urban layouts, reflecting and permeable materials, green roofs, and walls in reducing the urban heat island phenomenon and enhancing energy efficiency. The results highlight the impact of integrating climate-responsive solutions into urban planning to promote sustainable and comfortable environments. This study offers significant perspectives for architects, urban planners, and legislators who are seeking to enhance metropolitan environments by efficiently dealing with issues caused by climate change.