This study investigates morphological changes in the Nile River in El-Dahab Island, which is located in the metropolitan region of Cairo near the eastern Nile shore near Qorsaya Island, resulting from human interventions and the construction of stream bank protection structures. A two-dimensional model was developed to simulate morphological changes in the area. Results show significant channel changes due to decreased flows and sediment supply, particularly in recent decades. Erosion and deposition areas in the study region are presented in this paper. These findings will aid decision-makers in area development, navigation, and the protection of water structures and riverbanks. The results can also support analyses of sediment transport in the past twenty years and serve as a reference for future predictions of morphological changes in the area. A comparison was made between the measured cross sections of 2003 and the same area in 2020 by using the SMS (Surface-water Modeling System). The model is used to simulate morphological changes in water level, bed elevation, and sedimentation in the study area.