The involvement of (ROS) has been linked to the toxicity of various pesticides. Our study was designed to investigate the induction of oxidative stress and hepatotoxicity by cypermethrin type II synthetic pyrethroids in male rats and discussed the role of Panax ginseng supplementation in reducing hepatic oxidative stress and liver damage. Rats were given either Panax mixed with diet (0.1%diet/day) or cypermethrin (9.4mg/kg/b.wt) orally (5 times/week) or both of them for a period of 3 months. Serum and liver tissue samples were collected at one-month intervals during the period of an experiment for biochemical assay, oxidative stress biomarkers, and histopathological examination. Analysis of variance (ANOVA) added revealed that oral administration of cypermethrin significantly reduced the level of glutathione (GSH) and the activity of antioxidant enzymes superoxide dismutase and catalase (SOD and CAT), while the level of lipid peroxidation (MDA) was elevated indicating the presence of oxidative stress. Regarding biochemical analysis cypermethrin exposure significantly raised the activities of aminotransferase enzymes, ALP, total bilirubin, total cholesterol, triglycerides, and LDL from the beginning (first month) except total bilirubin increased from 2^nd month of treatment. Meanwhile, total protein, albumin, and HDL are significantly depleted at the beginning of the experiment to reach the highest changes at the end of the experiment (third month) in a time-dependent manner. That corresponds to the extensive liver damage and histopathological findings in the liver. On the other hand administration of Panax significantly reduced the toxic effect of cypermethrin on the biochemical constituents, and histo-architecture of the liver and restored the antioxidant capacity in the liver.