Rabbit hemorrhagic disease (RHD) is a highly contagious disease of domestic and wild rabbit species caused by a lagovirus belonging to the Caliciviridae family. RHD is characterized by acute liver necrosis and a high mortality rate. The aim of this study was to recognize and describe RHDV (type 2) in naturally and experimentally infected rabbits, describing the histopathological alterations in the liver, spleen, lungs, and kidney in various Egyptian governorates during the period from January 2019 to May 2022. Nineteen suspected liver samples were collected from outbreaks in nine governorates. Three strains out of ten positive liver samples were proved for RHD virus by hemagglutination test[]  and reverse transcriptase polymerase chain reaction.  Kafr Sheikh strain, Sohag strain, and Damiatta strain were inspected to study the pathological lesions associated with RHDV infection in naturally and experimentally infected rabbits