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317274

Histopathological and Ultrastructural Effects of Long-Term Administration of Sildenafil Citrate (Viagra®) on Nasal Mucosa of the Adult Male Albino Rat

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pathology

Abstract

One of the five primary human senses is smell which provides an individual's ability to detect health hazards such as fire or toxic fumes. Sildenafil citrate (Viagra) is a drug approved for erectile dysfunction. At high doses, sildenafil causes mild visual symptoms and is toxic to the cochlea.  In addition, approximately 20% of patients treated with sildenafil complained of nasal congestion and decreased olfactory sensitivity. The purpose of this study was to look at the effect of long-term sildenafil administration on the olfactory mucosa in rats. The animals were divided evenly into two groups of 15 each, every rat weighed 200-250g. The rats in the control group (group I) were given 0.5 ml of distilled water and rats in group II were given 10 mg sildenafil citrate /kg body weight dissolved in 0.5 ml of distilled water, respectively via Gastric tube once daily/every day for three months. After the end of the trial, rats were euthanized using pentobarbitone. After death was confirmed, nasal mucous membranes obtained from rats were fixed in 10% formalin solution for histopathological examination. Other sections were preserved in glutaraldehyde 2.5% for electron microscopy. The second group showed degeneration of the mucous membrane of the respiratory and olfactory tracts. In addition to congestion of the submucosal vessels, loss, and shortening of the olfactory cilia with degenerative changes were observed. Electron microscopy revealed the normal structure of group I. The olfactory surface of 100 mg of sildenafil revealed numerous olfactory vesicles with a rough surface and loss of ciliary surface along with loss of bipolarity of both cilia and dendrites.

DOI

10.21608/scvmj.2023.232039.1141

Keywords

Scanning electron microscope, Olfactory mucosa, respiratory mucosa

Authors

First Name

Diaa El Din

Last Name

El-Hennawi

MiddleName

Mohamed

Affiliation

Department of Otolaryngology, Faculty of Medicine Suez Canal University, Ismailia - Egypt.

Email

diaaeldin.alhnawy@med.suez.edu.eg

City

-

Orcid

-

First Name

Rifaat

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Otolaryngology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

mohamed_abdallah@med.suez.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

El Tabbakh

MiddleName

-

Affiliation

Department of Otolaryngology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

mohamed_eltabakh@med.suez.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdelrehem

MiddleName

Salama

Affiliation

Faculty of Medicine, Suez Canal University- ENT Department, Police Hospital – Nasr City, Egypt.

Email

ahmed.salama@med.suez.edu.eg

City

-

Orcid

-

First Name

Amina

Last Name

Dessouki

MiddleName

Ali

Affiliation

Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Email

aminadessouki@vet.suez.edu.eg

City

ismailia

Orcid

0000-0001-5302-9438

Volume

28

Article Issue

2

Related Issue

42397

Issue Date

2023-12-01

Receive Date

2023-08-27

Publish Date

2023-12-01

Page Start

379

Page End

389

Print ISSN

1110-6298

Online ISSN

2682-3284

Article File

SCVMJ_Volume 28_Issue 2_Pages 379-389.pdf

PDF . 1.2MB

Link

https://scvmj.journals.ekb.eg/article_317274.html

Detail API

https://scvmj.journals.ekb.eg/service?article_code=317274

Order

10

Type

Original Article

Type Code

992

Publication Type

Journal

Publication Title

Suez Canal Veterinary Medical Journal. SCVMJ

Publication Link

https://scvmj.journals.ekb.eg/

MainTitle

Histopathological and Ultrastructural Effects of Long-Term Administration of Sildenafil Citrate (Viagra®) on Nasal Mucosa of the Adult Male Albino Rat

Details

Type

Article

Created At

24 Dec 2024