The study was designed to investigate the protective efficacy of some additives on ration naturally contaminated with ochratoxin broiler chicks. Seven ration samples were randomly collected for the detection of ochratoxin using a fluorometer. Ninety, one-day-old broiler Ross-308 chicks were divided into three groups (A, B, and C with 30 birds in each, 3 replicates per group). Group (A) chicks received a ration containing 5.3 ppb ochratoxin (control positive), Group (B) chicks received 5.3 ppb ochratoxin and HASCS, Avi Bac., Pro power Byg35, while Group (C) chicks received a ration free from either ochratoxin or treatments (control negative). Clinicopathological signs, growth performance, Hematological, and biochemical studies were recorded. Serum biochemical analysis results confirmed hepatotoxic and nephrotoxic hazard, which manifested by significant increases in GGT, ALT, Uric acid, cholesterol, Total bilirubin, and a non-significant increase of creatinine that was associated with a significant decrease in hemoglobin, lymphocyte heterophile basophile, monocyte and eosinophile. In conclusion, the evaluated feed additive has a significant protective effect against the ochratoxin hepatotoxic and nephrotoxic effect on growing broiler chicks.