One of the most common canine maladies seen by veterinarians worldwide is gastroenteritis. The purpose of this investigation was to analyze hematological and biochemical changes in canines suffering from gastroenteritis. One hundred canines of varying ages and breeds participated in the study, with ten considered "appearing healthy" and ninety considered "diseased." A total of 200 blood samples, representing both groups, were taken for hematological and biochemical analysis. Clinical manifestations included vomiting, diarrhea that ranged from watery yellow to bloody, loss of appetite, mild, moderate, and severe dehydration, as indicated by an STT, increased respiratory rate, and a tachycardic rate. Diseased dogs typically exhibit elevated levels of the biochemical markers AST and ALT, and decreased levels of the hematological markers Hb, PCV, RBCs, platelets, WBCs, neutrophils, lymphocytes, monocytes, total protein, albumin, globulin, sodium, calcium, chloride, potassium, and iron