Background: Lupine seeds  (Lupinus albus ) are good sources of protein which can regulate intestinal absorption of glucose and attenuate risk of hyperlipidemia and T2DM diseases. consumption of lupines induces hypoglycemic effects in diabetic patients, which decreases hyperglycemic features.. Gamma Conglutin (Cγ) lupines induce cellular glucose uptake, and improve glucose metabolism and insulin sensitivity. γ-conglutin is significantly decreases the levels of fasting glucose, improves glucose tolerance and insulin resistance (IR), and increases cellular glucose uptake in diabetic rats. Aim: In this study we aimed to evaluate and compare between the preclinical therapeutic effects of the γ-conglutin whole white lupine seeds powder  (CγWWLSP ) (Lupines albus L./Lupinus terms L./sweet lupines) and the γ-conglutin standard lupine proteins isolate (CγSLPI/reference commercial extract) on the high fat high cholesterol diet feeding plus streptozotocin injection (HFHCD+STZ)-induced T2DM male albino rats model. We targeted to determine hypoglycemic, hyperinsulinemia, powerful β-cells homeostasis, peripheral insulin sensitivity, cellular glucose uptake and hypolipidemic properties of CγWWLSP and CγSLPI on the HFHCD+STZ-induced T2DM male albino rats model. The hepatic and pancreatic histopathological examinations were performed to evaluate preclinical therapeutic potentials of CγWWLSP and CγSLPI on the liver and pancreas tissue sections of the HFHCD+STZ-induced T2DM  male albino rats model  Methods: the experiment, the rats were divided into two main groups including SNC group  (standard negative control )/ 12 rats) and HFHCD group (High fate High cholesterol Diet)/ 72 rats) which  later divided into 6   groups (positive control ( diabetes ) – orally administrated groups with 300 mg CγWWLSP ,  600 mg CγWWLSP , 100 mg CγSLPI , 200 mg CγSLPI and  5 mg  decalazide ) .