Aim: to assess the topical use of ciprofloxacin gel's microbiological, clinical, and
radiographic efficacy in patients with stage I or II, grade A periodontitis as an adjuvant
treatment. Subjects and methods: The mean age of the 14 patients was 39±6.55,
and they tested positive for Aa. They also had grade A periodontitis, stage I or II. Two
patient groups were identified: Patients in Group I received non-surgical periodontal
therapy together with an intrapocket application of ciprofloxacin gel, and patients in
Group II received non-surgical periodontal therapy exclusively. Results: After one and
three months, a statistically significant difference (p-value <0.05) was seen between
the baseline. Furthermore, there were statistically significant variations in the gingival
index between the two groups at various time intervals from the baseline, as well as a
statistically significant variation in the probing depth measurement in each group at
various time intervals from the baseline. The clinical attachment level measurements of
the two groups were compared at different intervals. There were statistically significant
differences between the clinical attachment level measurements of the two groups when
compared at different intervals to the baseline. There was no statistically significant
difference in the radiographic marginal bone level between the two groups at one, three,
or six months from the baseline. Conclusion: Compared to scaling and root planning
alone, adjunctive use of ciprofloxacin in-situ gel 1% proved to have a positive impact
on both clinical and microbiological parameters of Aa copy number in patients with
stage I and II grade A periodontitis.