Aim: Aim of this study was to compare between cement retained versus screw
retained prothetheis on dental implant. Subjects and Methods: Eleven patients with
22 missing teeth were randomly divided into two groups. Group (I) 11 sites with single
missed tooth received an implant then cement retained prosthesis. Group (II) 11 sites
with single missed tooth received an implant then a screw retained prosthesis. Clinical
and biochemical parameters were taken at baseline 1 and 3 months while radiographic
parameters were taken at baseline, 1 and 6 months. Results: both groups showed a
non-significant difference in mPI, mBI , PIPD and BD. Cement retained group showed
higher bone loss than screw retained (p=0.002) (p<0.001) respectively. IL-1β and
MMP-9 showed increased expression in peri-implant crevicular fluid around cement
retained more than screw retained prosthesis. Conclusion: screw-retained implant
prothehesis gives better result from biological point of view than cement-retained
implant prosthesis.