Aim: The present study was designed to evaluate platelet-rich fibrin
(PRF) as a scaffold in regeneration of pulp in young permanent anterior teeth.
Subjects and Methods: The revascularization procedure was performed in 16 cases of
necrotic immature permanent teeth in all the 16 cases, the intracanal disinfection was
performed with limited mechanical instrumentation, abundant irrigation, and calcium
hydroxide. At the final appointment, intracanal bleeding was induced. In one group
PRF will be obtained by centrifuging the blood withdrawn from the patients, well
placed with a plugger into the root canal until it reaches up to the coronal 1/3rd level of
the canal, in the second group laceration of the periapical area will be done to induce
bleeding then MTA will be used to direct contact with the tissue then cavity restored
with glass ionomer cement.Clinical and radiographic follow up will be done at 3,6,9and
12 months intervals. Results: After the follow-up, it was observed that the first group
(PRF) had better radiographic results compared to the second group (blood clots). The
first group also showed excellent periapical healing, root completion, and thickening
of root canal walls. However, the second group experienced delays in the regeneration
process. Conclusion: Regenerative endodontic treatment may be a good alternative for
the treatment of young permanent teeth instead of traditional methods that result in a
closed apex without any root development.