Aim: This study sought to assess the effectiveness of using bone marrow concentrate injections to treat advanced internal derangement of the Temporomandibular 
Joint (TMJ). Subjects and methods: Ten patients diagnosed with advanced internal 
derangement of the TMJ were included in this retrospective analysis. All ten patients 
underwent treatment with bone marrow concentrate injections. The post-treatment 
effectiveness was assessed by monitoring the patients for six months. Additionally, 
MRI scans were used to evaluate the outcome at the end of the follow-up period. 
Results: The use of bone marrow concentrate injections for treating advanced internal derangement of the TMJ led to significant reductions in pain and notable improvements in maximum interincisal opening after the six-month observation period. 
Conclusion: Injecting bone marrow concentrate into the TMJ proves to be a dependable and technically feasible approach for managing advanced internal derangement of 
the Temporomandibular Joint.