Aim: Evaluation of the lateral sinus lift technique using 3D-printed surgical guide 
with simultaneous implant placement. Subjects and methods: Using preoperative 
cone-beam computed tomography (CBCT) and a precise picture of the dentition, a 
surgical guide was created. Lateral sinus lift was performed by using a 3 dimensionalprinted surgical guide for lateral window osteotomy and implant placement. CBCT was 
obtained and maxillary sinus volume (MSV) was measured preoperatively, immediately 
postoperatively, and 6 months postoperatively. Implant stability (ISQ) using Osstell® 
was also assessed immediately postoperatively and 6 months postoperatively. 
Results MSV Immediate postoperative showed a significant decreased from the 
preoperative. Moreover, 6 months postoperative showed significant decrease from 
preoperative (p <0.001). Buccal showed a significantly more bone gain than palatal 
in immediate and after 6 months postoperative (P<0.05). A significantly increased 
bone density and ISQ six months postoperatively was reported compared to immediate 
postoperative bone density and ISQ (P<0.001). Conclusion: Lateral MS floor elevation 
using a 3D-printed surgical guide with simultaneous implant placement provides a faster 
operation and ensures predictable results, with superior sinus volume preservation, 
bone density, and ISQ.