Aim: This study was conducted to compare between conventional and digital 
complete dentures as regard prosthesis retention, level of bacteria and/ or yeast present.
Subjects and Methods: Ten completely edentulous patients every patient was received 
conventional and digital complete dentures. The patients were allowed to wear each 
denture, and the test of retention for both dentures was measured. Plaque samples were 
collected from intaglio surfaces of complete dentures to culture for any colonization 
of bacteria and/or yeasts. Results: When compared conventional and digital complete 
dentures there were a significant increase in retention in digital denture and a significant 
increase in microbial growth in conventional denture. Conclusion: According this 
study the retention of digital denture significant higher and digital dentures showed less 
microbial colonization than conventional dentures.