Aims: This study was performed to evaluate clinically and biochemically the 
efficacy of ciprofloxacin as adjunctive in non-surgical treatment of stage I and II Grade 
A periodontitis, through evaluation of the clinical parameters as well as IL-6 level 
in GCF.. Subjects and Methods: 20 patients of both sex divided into two groups. 
Group 1 included 10 patients were treated by only conventional periodontal therapy 
(scaling and root planing). Group 2 included 10 patients were treated by scaling and 
root planing followed by topical intra pocket application of Ciprofloxacin gel 1%. 
Evaluated clinically at baseline, 1 month and 3 months. The biochemical evaluation 
of interleukin 6 was done at baseline, 1 month and 3 months. Results: Clinical 
parameter showed a statistically significant differences in both groups at the different 
intervals when compared to the baseline. All parameter showed in group 2 statistically 
significant difference between 1 month and 3 month. When groups 2 was compared 
to group 1 all parameter showed statistically reduction at 1 month and 3 months in 
relation to baseline. Biochemical marker showed a statistically significant differences 
were showed in both groups at the different intervals when compared to the baseline 
with statistically significant difference between 1 month and 3 month. Conclusion: The 
topically applied ciprofloxacin seamed to exhibit a synergistic action in treatment of 
stage I and II grade A periodontitis