Aim: This study aimed to compare the efficacy of ND: YAG laser and PRP in the 
treatment of chronic periodontitis using a split-mouth design. Subjects and Methods:
A randomized clinical trial was conducted on 30 patients diagnosed with chronic 
periodontitis. Each patient received ND: YAG laser treatment on one side of the mouth 
and PRP on the other. Clinical parameters include Probing Depth (PD), and Gingival 
Index (GI). Clinical Attachment Level (CAL), Plaque Index (PI), and radiographic 
bony defect were assessed at baseline, 1 month, and 6 months post-treatment. The 
Mann- Whitney U test was used for statistical analysis. Results: Treatment with the 
ND: YAG laser led to a significantly larger decrease in all clinical parameters when 
contrasted with the PRP treatment. This was statistically significant at both the 1-month 
and 6-month post-treatment evaluations (p\<0.001). Those who received ND: YAG 
laser treatment showed reductions in PD, GI, CAL, PI, and radiographic bony defects.
Conclusion: The ND YAG laser treatment demonstrated superior efficacy over PRP in 
the management of chronic periodontitis. These findings suggest that the ND YAG laser 
could be a more effective treatment modality for chronic periodontitis, contributing 
to improved patient outcomes. However, future studies with larger sample sizes and 
longer follow-up periods are warranted to confirm and extend these findings modality