Aim: The goal of this study was to assess the nanoleakage of nano-filled resin
composites utilizing various adhesive systems at varying dentin depths. Subjects and
methods: In this investigation, 120 freshly removed human molars were tested. The
chosen teeth were randomly divided into two main groups (n=60), with each main
group being divided into two smaller groups (n=30) based on the adhesive system (etch-
&rinse mode and self-etch mode of application). According to the superficial and deep < /div>
dentin layers used in the adhesion process, each small group was separated into two
even smaller subgroups (n = 15). Each smaller group was divided into three different
categories depending on the lengths of storage (24 hours, 3 months, and 6 months) (n
= 5). Each tooth was gradually reconstructed using the nanofilled resin composite. The
specimens were cut longitudinally in the mesio-distal and bucco-lingual orientations
to create resin-dentin beams. For the purpose of assessing nanoleakage, the beam was
submerged in silver nitrate. Results: There was no statistically significant difference
between groups in terms of the effect of application mode or dentin depth on nanoleakage,
however there was a statistically significant increase in median nano-leakage scores
from 24 hours to 3 months and 3 to 6 months of storage duration. Conclusion: The use
of both bonding chemicals helps to reduce resin composite leakage. Since the self-etch
adhesive system excelled total etch in deep cavities, it is advised to use it. While the
total etch adhesive method, is advised for use in superficial cavities.