Aim: the use of probiotic gel may be considered as beneficial treatment for
periodontitis. This study was directed to evaluate the possible effect of topically applied
probiotics on Interleukin-10 (IL-10) and osteoprotegerin (OPG) combined with scaling
and root planning (SRP) in treatment of stage І and П grade A periodontitis. Subjects
and Methods: 18 female patients were divided randomly into two equal groups. Group < /div>
I (PG): received SRP combined with topically applied probiotics gel. Group II(CG):
received SRP only. All patients were received phase I periodontal therapy. Then all
patients were evaluated clinically and biochemically at base line, one month and three
months after periodontal therapy Results recorded, tabulated and statistically analyzed
using SPSS (statistical package for social sciences). Results: Clinical parameters such
as plaque index (PI), gingival index (GI), probing pocket depth (PPD) and clinical
attachment level (CAL) were evaluated. In all groups there was a significant reduction
regarding the clinical parameters. There was insignificant better results regarding
PI and GI in group I. while, there was significant better results regarding PPD and
CAL in group I than group II. OPG levels showed insignificant better results in PG
than CG but IL-10 levels showed significant better results in PG over time than CG.
Conclusion: Adjunctive topically applied probiotic gel exhibited anti inflammatory
effect through the significant expression of IL-10 after treatment of stage I and II grade
A periodontitis patients. On the other hand seemed to be non significantly improve the
bone formation through the limited expression of OPG