After the majority of the Egyptian and American citizens had received the vaccinations against coronavirus pandemic, most public and private institutions, like schools, factories, etc., in both societies began to reopen in favor of the economy. Although the vaccinated and unvaccinated people were in a bad need of following the additional protective behaviors required to control the pandemic, many people began to live naturally without following the precautionary measures. Therefore, the researcher selects cartoons from the American and Egyptian websites to cover such a period of coping with the pandemic. The researcher aims to investigate the message encoded by the cartoonists, how it is decoded by the cartoon reader, and the strategies involved in this encoding-decoding process in the data under investigation. Data for the study comprise six purposively selected online cartoons (3 Egyptian cartoons and 3 American ones). The researcher uses insights from relevance theory to analyze the explicature, implicated premises and implicated conclusions of the data under investigation. The present study concludes that relevance theory proves to be an effective tool in analyzing the multimodal texts as represented in COVID-19 cartoons. Another conclusion is that the cognitive context (i.e. background knowledge) plays a vital role in the process of inferring the implicature of the Coronavirus cartoons.