Multimodal communication has recently become popular. Multimodality is concerned with the way the different semiotic modes (e.g. color, gesture, gaze, etc.) are combined with a sociocultural domain to create a semiotic product or event (Kress and van Leeuwen, 2001). A visual mode can be found in multimodal texts such as magazines, newspapers, advertisements, textbooks, cartoons, etc. Cartoons, as multimodal texts, are found in newspapers, social networks, and magazines. Data for the study comprise six purposively selected online Coronavirus cartoons (3 Egyptian and 3 American cartoons). The present study aims to analyze the verbal and the non-verbal modes that contribute to meaning making in the selected Egyptian and American Coronavirus cartoons. The researcher adopts Kress and van Leeuwen's (2006) theory of social semiotics to analyze the data under investigation on the verbal and the non-verbal levels. Kress and van Leeuwen's theory is based on Halliday's (1985) Systemic Functional Grammar (SFG) and its three metafunctions. One conclusion confirms that the visual modes, along with verbal ones, used in the Egyptian and American cartoons about the coronavirus enable the cartoon viewers to visualize the epidemiological status and increase public awareness as regards the COVID-19 pandemic. Moreover, one can confirm that understanding the three metafunctions in visual social semiotic approach is essential for a cartoon viewer to fully grasp meanings conveyed in the coronavirus cartoons in the selected data.